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Structure of 446-31-1
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4-Amino-2-fluorobenzoic acid features a strategically positioned amino group and fluorine atom on the aromatic ring, enabling enhanced electronic modulation and metabolic stability. This combination supports efficient incorporation into bioactive scaffolds and facilitates directed functionalization in medicinal chemistry campaigns.
4-Amino-2-fluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard amide coupling, Suzuki-Miyaura, and Ullmann-type reactions. Its ortho-fluoro and amino groups offer complementary reactivity for sequential functionalization, while the carboxylic acid facilitates direct derivatization or salt formation. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in multi-step syntheses and API development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: