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Structure of 452-74-4
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1-Bromo-2-fluoro-4-methylbenzene features a strategically positioned bromo and fluoro substituent on a methylated benzene ring, enabling selective cross-coupling reactions. The electron-deficient aryl halide integrates readily into palladium-catalyzed transformations, while the para-methyl group enhances solubility and stabilizes reaction intermediates under standard conditions.
1-Bromo-2-fluoro-4-methylbenzene serves as a versatile building block in cross-coupling reactions, enabling efficient construction of substituted biaryls and heterocycles. The bromo group facilitates palladium-catalyzed coupling with minimal interference from the ortho-fluoro and para-methyl substituents, offering excellent functional group tolerance. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for iterative synthesis workflows in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: