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Structure of 5100-97-0
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1-Bromo-2-fluoro-4,5-dimethylbenzene features a uniquely activated aromatic core with complementary halogen handles. The ortho-fluoro and bromo substituents enable selective cross-coupling reactions, while the two methyl groups enhance solubility and steric protection. This bench-stable derivative serves as a key building block in constructing complex heterocycles and functionalized biaryls under standard conditions.
1-Bromo-2-fluoro-4,5-dimethylbenzene serves as a versatile aryl halide building block in cross-coupling reactions, enabling efficient construction of biaryl scaffolds under palladium catalysis. The ortho-fluoro substituent enhances reactivity in Suzuki-Miyaura and Negishi couplings while maintaining stability during storage and handling. Its methyl groups provide steric and electronic modulation, facilitating selective functionalization and serving as a platform for further derivatization in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319
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Precautionary Statements : P210-P264-P280-P302+P352-P362-P370+P378-P501
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Lot numbers can be found on the outside label of a product: