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Structure of 452-77-7
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3-Fluoro-4-methylaniline features a fluorine atom at the meta position and a methyl group at the para position relative to the amine, delivering enhanced electron density and improved solubility in organic media. This substitution pattern enables selective coupling reactions under mild conditions, facilitating efficient access to functionalized anilines for pharmaceutical intermediates and agrochemical synthesis.
3-Fluoro-4-methylaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and para-methyl substituents provide enhanced metabolic stability and modulate electronic properties for target engagement. The compound exhibits bench stability, facilitates straightforward purification, and functions effectively in amide couplings, Suzuki-Miyaura reactions, and electrophilic substitutions common to API development workflows.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H227-H300-H312+H332-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: