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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-methylaniline

  • CAS No. 452-84-6

  • Cat. No. CS-D0820
  • Purity≥98%
  • MDL No.MFCD00007654
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-methylaniline|CS-D0820

Structure of 452-84-6

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Description

2-Fluoro-5-methylaniline features a fluorine atom at the ortho position relative to the amino group and a methyl substituent at the para position, delivering enhanced electronic modulation and steric influence. This configuration supports improved reactivity in coupling processes and facilitates integration into complex heterocyclic scaffolds. The compound exhibits bench-stable handling characteristics and is compatible with standard synthetic protocols.

Application

2-Fluoro-5-methylaniline serves as a valuable building block for pharmaceutical and agrochemical synthesis, offering a trifunctional scaffold with ortho-fluorine and meta-methyl substituents. Its enhanced electronic profile facilitates selective electrophilic substitution and coupling reactions, while the aromatic amine functions as a key handle in Suzuki-Miyaura and Ullmann-type transformations. Bench-stable and readily purified via crystallization, it enables efficient access to fluorinated heterocycles and bioactive scaffolds.

General Information

  • CAS No. 452-84-6
  • Cat. No. CS-D0820
  • Purity ≥98%
  • MDL No. MFCD00007654
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FN
  • Molecular Weight None
  • Synonym(s) 6-Fluoro-m-toluidine
  • SMILES NC1=C(F)C=CC(C)=C1

Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.71632
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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