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Structure of 452-84-6
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2-Fluoro-5-methylaniline features a fluorine atom at the ortho position relative to the amino group and a methyl substituent at the para position, delivering enhanced electronic modulation and steric influence. This configuration supports improved reactivity in coupling processes and facilitates integration into complex heterocyclic scaffolds. The compound exhibits bench-stable handling characteristics and is compatible with standard synthetic protocols.
2-Fluoro-5-methylaniline serves as a valuable building block for pharmaceutical and agrochemical synthesis, offering a trifunctional scaffold with ortho-fluorine and meta-methyl substituents. Its enhanced electronic profile facilitates selective electrophilic substitution and coupling reactions, while the aromatic amine functions as a key handle in Suzuki-Miyaura and Ullmann-type transformations. Bench-stable and readily purified via crystallization, it enables efficient access to fluorinated heterocycles and bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: