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Structure of 454-81-9
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2-Amino-4-(trifluoromethyl)phenol features a strategically positioned trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the ortho-amino functionality enables direct coupling in pharmaceutical intermediates. This bench-stable compound integrates readily into heterocyclic systems under standard conditions, offering robust reactivity for advanced synthetic applications.
2-Amino-4-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant heterocyclic scaffolds. Its ortho-amino and phenolic functionalities offer complementary reactivity for electrophilic substitution, cyclization, and coupling reactions. The trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the compound exhibits good bench stability and ease of purification—ideal for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: