Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

[1-(Aminomethyl)cyclopropyl]methanol

  • CAS No. 45434-02-4

  • Cat. No. CS-0072215
  • Purity≥95%
  • MDL No.MFCD09864388

*For research and further manufacturing use only, not for direct human use.

[1-(Aminomethyl)cyclopropyl]methanol|CS-0072215

Structure of 45434-02-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 45434-02-4
  • Cat. No. CS-0072215
  • Purity ≥95%
  • MDL No. MFCD09864388
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight None
  • Synonym(s) None
  • SMILES NCC1(CO)CC1

Description

This cyclopropylmethanol derivative features a primary amine tethered to the cyclopropyl ring via a methylene linker. The aminomethyl group imparts nucleophilic character and facilitates conjugation or derivatization, while the strained cyclopropyl moiety enhances rigidity and metabolic stability. Ideal for bioconjugation and medicinal chemistry applications requiring a stable, compact scaffold with accessible nitrogen functionality.

Application

[1-(Aminomethyl)cyclopropyl]methanol serves as a versatile building block for medicinal chemistry, enabling the construction of bioactive cyclopropyl-containing scaffolds. Its primary amine and hydroxymethyl groups offer orthogonal functionalization sites, facilitating downstream derivatization via amidation, alkylation, or oxidation. The molecule exhibits good bench stability and solubility in common organic solvents, supporting efficient purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • Ethyl 1-(cyanomethyl)cyclopropanecarboxylate|CS-0747763
      3697-69-6
    • ~%
    • In-stock
      [1-(Aminomethyl)cyclopropyl]methanol|CS-0072215
      45434-02-4

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong Patent: WO2011/71716 A1, 2011 ; Location in patent: Page/Page column 76 ; WO 2011/071716 A1
  • Route2
    • null|null
      6914-80-3
    • ~79%
    • In-stock
      [1-(Aminomethyl)cyclopropyl]methanol|CS-0072215
      45434-02-4

    References

    • Buchholz, Mirko; Heiser, Ulrich; Schilling, Stephan; Niestroj, Andre J.; Zunkel, Katrin; Demuth, Hans-Ulrich Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 664 - 677
  • Route3

    References

    • Newman; Broger; LaPidus; Tye Journal of medicinal chemistry, 1972 , vol. 15, # 10 p. 1003 - 1006

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H302-H314-H335-H413
Precautionary Statements : P210-P261-P280

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   46.25
  • LogP   -0.2824
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • [1-(Aminomethyl)cyclopropyl]methanol sigma[1-(Aminomethyl)cyclopropyl]methanol manufacturer[1-(Aminomethyl)cyclopropyl]methanol price[1-(Aminomethyl)cyclopropyl]methanol structure[1-(Aminomethyl)cyclopropyl]methanol SDSbuy [1-(Aminomethyl)cyclopropyl]methanol[1-(Aminomethyl)cyclopropyl]methanol supplier[1-(Aminomethyl)cyclopropyl]methanol uses[1-(Aminomethyl)cyclopropyl]methanol molecular weightprice of [1-(Aminomethyl)cyclopropyl]methanol[1-(Aminomethyl)cyclopropyl]methanol chemical name formula of [1-(Aminomethyl)cyclopropyl]methanol
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label