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CS-W001157 4
Total: USD 88.00

4-Acetylbenzene-1-sulfonyl fluoride

  • CAS No. 455-25-4

  • Cat. No. CS-0234231
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Acetylbenzene-1-sulfonyl fluoride|CS-0234231

Structure of 455-25-4

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Description

4-Acetylbenzene-1-sulfonyl fluoride is a reactive acylating agent featuring a sulfonyl fluoride group flanked by an electron-withdrawing acetyl substituent. This combination enhances electrophilicity at the sulfonyl center, enabling efficient coupling with nucleophiles in mild conditions. The molecule exhibits bench-stable handling characteristics and delivers high functional group tolerance, making it well-suited for selective protein labeling and bioconjugation workflows.

Application

4-Acetylbenzene-1-sulfonyl fluoride serves as a versatile electrophilic sulfonylating agent, enabling efficient introduction of sulfonate groups under mild conditions. Its acetyl functionality provides orthogonal reactivity for subsequent transformations, while the sulfonyl fluoride moiety offers high stability and compatibility with diverse functional groups. Ideal for late-stage functionalization in medicinal chemistry, it facilitates rapid access to sulfonamide-containing scaffolds with excellent bench stability and straightforward purification.

General Information

  • CAS No. 455-25-4
  • Cat. No. CS-0234231
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃S
  • Molecular Weight 202.20
  • Synonym(s) None
  • SMILES O=S(C1=CC=C(C(C)=O)C=C1)(F)=O

Computational Chemistry Data

  • TPSA   51.21
  • LogP   1.5474
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H302-H314-H315
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

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