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5-Methyl-2-pyridinemethanamine

  • CAS No. 45715-08-0

  • Cat. No. CS-0019191
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD08752541

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-pyridinemethanamine|CS-0019191

Structure of 45715-08-0

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General Information

  • CAS No. 45715-08-0
  • Cat. No. CS-0019191
  • Purity ≥95%
  • MDL No. MFCD08752541
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight None
  • Synonym(s) 2-(Aminomethyl)-5-methylpyridine; [(5-Methylpyridin-2-yl)methyl]amine; (5-Methylpyridin-2-yl)methanamine
  • SMILES NCC1=NC=C(C)C=C1

Description

5-Methyl-2-pyridinemethanamine delivers a sterically accessible pyridyl amine handle with enhanced electron density from the methyl substituent, enabling efficient coupling in ligand synthesis and functional material design under standard conditions.

Application

5-Methyl-2-pyridinemethanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard coupling and functionalization reactions. Its pyridyl nitrogen and methyl substituent provide favorable electronic and steric profiles for transition-metal-catalyzed transformations. The primary amine facilitates conjugation and derivatization under mild conditions, offering robust bench stability and ease of purification in multi-step syntheses.

Synthesis

  • Route1

    References

    • F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O'YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu Patent: WO2013/30138 A1, 2013 ; Location in patent: Page/Page column 104; 105 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.84872
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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