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CS-W001157 4
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(6-Methylpyridin-2-yl)methanamine

  • CAS No. 6627-60-7

  • Cat. No. CS-W003929
  • Molecule weight122.17
  • Purity≥97%
  • MDL No.MFCD05864530

*For research and further manufacturing use only, not for direct human use.

(6-Methylpyridin-2-yl)methanamine|CS-W003929

Structure of 6627-60-7

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General Information

  • CAS No. 6627-60-7
  • Cat. No. CS-W003929
  • Purity ≥97%
  • MDL No. MFCD05864530
  • Storage -20°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) 1-(6-methylpyridin-2-yl)methanamine
  • SMILES NCc1cccc(n1)C

Description

This bench-stable, moisture-tolerant amine features a pyridine ring with a methyl group at the 6-position and a methylene-linked primary amine at the 2-position. It integrates readily into ligand design for transition metal catalysis and serves as a key building block in medicinal chemistry scaffolds requiring nitrogen-rich heterocyclic frameworks.

Application

(6-Methylpyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles through direct functionalization at the pyridine nitrogen and side-chain amine. Its bench-stable nature and compatibility with standard coupling reactions facilitate straightforward incorporation into drug-like scaffolds, particularly in kinase inhibitors and CNS-targeted molecules. The methyl group enhances metabolic stability while maintaining favorable electronic properties for target binding.

Synthesis

  • Route1
    • [C(E)]-6-Methyl-2-pyridinecarboxaldehyde oxime|CS-0222388
      1265324-16-0
    • ~%
    • In-stock
      (6-Methylpyridin-2-yl)methanamine|CS-W003929
      6627-60-7

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6415,6420
  • Route2
    • null|null
      332179-68-7
    • ~%
    • In-stock
      (6-Methylpyridin-2-yl)methanamine|CS-W003929
      6627-60-7

    References

    • US2008/194650 A1, ; Page/Page column 29-30 ; US 20080194650 A1
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6415,6420

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.84872
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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