(4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid

Name: (4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid
Brand: ChemScene
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CAS No. 457613-78-4
Cat. No. CS-0060942
Purity≥96%
MDL No.MFCD10696663

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FedEx Limited Quantities Ground	$0.00
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(4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid|CS-0060942

Structure of 457613-78-4

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Description

This boronate moiety integrates a tert-butyl carbamate-protected piperazine ring, enabling selective conjugation in late-stage functionalization. The electron-deficient boronic acid group facilitates efficient Suzuki-Miyaura coupling under mild conditions, while the protected amine offers orthogonal reactivity for downstream derivatization.

Application

(4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. The piperazine core offers enhanced solubility and functional group tolerance, while the Boc-protected amine facilitates downstream deprotection and derivatization. Bench-stable and readily purified by flash chromatography, it supports scalable synthesis in medicinal chemistry and materials science applications.

General Information

CAS No. 457613-78-4
Cat. No. CS-0060942
Purity ≥96%
MDL No. MFCD10696663
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₃BN₂O₄
Molecular Weight 306.17
Synonym(s) 4-(4-BOC-Piperazino)phenylboronic acid
SMILES CC(C)(C)OC(=O)N1CCN(CC1)C2=CC=C(C=C2)B(O)O

Computational Chemistry Data

TPSA 73.24
LogP 0.4235
H_Acceptors 5
H_Donors 2
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Other Classifications

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid

CAS No. 457613-78-4

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