4,4-Difluorocyclohexan-1-amine

Name: 4,4-Difluorocyclohexan-1-amine
Brand: ChemScene
Availability: InStock
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CAS No. 458566-84-2
Cat. No. CS-0054630
Purity≥97%
MDL No.MFCD06409984

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4,4-Difluorocyclohexan-1-amine|CS-0054630

Structure of 458566-84-2

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Description

4,4-Difluorocyclohexan-1-amine features a rigid cyclohexane core with two fluorine atoms at the 4-position, imparting enhanced metabolic stability and modulated lipophilicity. The primary amine group enables facile conjugation, making this scaffold valuable for medicinal chemistry applications where controlled bioavailability and target engagement are critical.

Application

4,4-Difluorocyclohexan-1-amine serves as a valuable chiral building block in medicinal chemistry, offering enhanced metabolic stability and modulated lipophilicity due to the geminal difluoro substitution. The amine functionality enables straightforward derivatization via amidation, alkylation, or reductive amination, while the cyclohexane scaffold provides conformational rigidity beneficial for target engagement. Bench-stable and readily purified by standard techniques, it functions effectively in multi-step synthesis of bioactive molecules and pharmaceutical intermediates.

General Information

CAS No. 458566-84-2
Cat. No. CS-0054630
Purity ≥97%
MDL No. MFCD06409984
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁F₂N
Molecular Weight 135.16
Synonym(s) 4,4-Difluorocyclohexanamine
SMILES NC1CCC(F)(F)CC1

Computational Chemistry Data

TPSA 26.02
LogP 1.523
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Fatty ring compounds Cyclohexane compounds

Key Words

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4,4-Difluorocyclohexan-1-amine

CAS No. 458566-84-2

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