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Structure of 460081-20-3
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Ethyl 2-bromooxazole-4-carboxylate features a brominated oxazole scaffold with a pendant ethyl ester, enabling direct functionalization in heterocyclic synthesis. This bench-stable reagent integrates readily into cross-coupling and nucleophilic substitution workflows, offering high regiocontrol at the C2 position.
Ethyl 2-bromooxazole-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the C2 position via palladium-catalyzed cross-coupling reactions. Its bromine substituent exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the oxazole ring provides metabolic stability and structural rigidity. The ester group allows for further derivatization, including hydrolysis to the carboxylic acid or reduction to the alcohol. Bench-stable and readily purified by flash chromatography, it functions as a reliable scaffold for medicinal chemistry campaigns targeting kinase inhibitors and antiviral agents.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: