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Structure of 461-82-5
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4-(Trifluoromethoxy)aniline was used in the synthesis of:side-group liquid-crystalline polymethacrylates with fluorine-containing mesogensderivatives of 3-(quinolin-3-yl)acrylatesseries of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves
4-(Trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of electron-withdrawing trifluoromethoxy groups into aromatic scaffolds. Its aniline functionality facilitates nucleophilic substitution, palladium-catalyzed coupling reactions, and electrophilic functionalization under standard conditions. The compound exhibits good bench stability and compatibility with common protecting group strategies, supporting efficient route development for complex heterocyclic systems and API intermediates.
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GHS No : GHS05,GHS06,GHS08
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Signal Word : Danger
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UN#: 2941
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H227-H301-H310-H315-H318-H373
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Precautionary Statements : P210-P260-P262-P264-P270-P280-P302+P352-P330-P361+P364-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: