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Structure of 828-27-3
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4-(Trifluoromethoxy)phenol features a trifluoromethoxy group appended to the para position of a phenolic scaffold, imparting enhanced electron-withdrawing character and metabolic stability. This combination enables robust participation in coupling reactions and facilitates integration into bioactive scaffolds requiring halogenated aromatic handles.
4-(Trifluoromethoxy)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct functionalization at the phenolic hydroxyl group. Its trifluoromethoxy substituent imparts enhanced metabolic stability and lipophilicity, while the aromatic framework supports diverse coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in standard cross-coupling, etherification, and electrophilic substitution protocols.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2922
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Class : 8 (6.1)
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Packing Group : Ⅱ
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Hazard Statements : H227-H301-H314-H412
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Precautionary Statements : P210-P260-P264-P270-P273-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: