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Structure of 461451-63-8
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5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile delivers a fluorinated aryl boronate moiety paired with a nitrile handle, enabling efficient Suzuki-Miyaura coupling under standard conditions. The tetramethylborolane group ensures high stability and moisture tolerance, while the para-fluorine facilitates downstream functionalization. This bench-stable reagent integrates seamlessly into complex molecule assembly workflows.
5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The nitrile group provides a handle for downstream functionalization, while the tetramethyl-substituted dioxaborolane enhances stability and shelf life. It reacts reliably with aryl halides and pseudohalides under standard catalytic conditions, enabling efficient construction of biaryl and heteroaryl scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: