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CS-W001157 4
Total: USD 88.00

4-Bromo-2-chlorobenzotrifluoride

  • CAS No. 467435-07-0

  • Cat. No. CS-W012520
  • Purity≥98%
  • MDL No.MFCD08459292

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-chlorobenzotrifluoride|CS-W012520

Structure of 467435-07-0

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General Information

  • CAS No. 467435-07-0
  • Cat. No. CS-W012520
  • Purity ≥98%
  • MDL No. MFCD08459292
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrClF₃
  • Molecular Weight None
  • Synonym(s) benzene, 4-bromo-2-chloro-1-(trifluoromethyl)-
  • SMILES FC(F)(F)C1=CC=C(Br)C=C1Cl

Description

4-Bromo-2-chlorobenzotrifluoride features a trifluoromethyl group flanked by bromo and chloro substituents at the para and ortho positions, respectively, delivering enhanced electron-withdrawal and metabolic stability. This aryl halide serves as a key building block in pharmaceutical synthesis, enabling palladium-catalyzed cross-coupling reactions under standard conditions. The molecule exhibits excellent bench stability and solubility in common organic solvents, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • ACTELION PHARMACEUTICALS LTD Patent: WO2008/78291 A1, 2008 ; Location in patent: Page/Page column 42 ; WO 2008/078291 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.1213
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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