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Structure of 468718-16-3
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5-(Trifluoromethyl)-1H-indole-3-carbaldehyde features a trifluoromethyl group at the 5-position of the indole core, enhancing electron-withdrawal and metabolic stability. The aldehyde functionality at the 3-position enables direct coupling in Ullmann or Suzuki-Miyaura reactions. This scaffold integrates readily into bioactive molecules for medicinal chemistry campaigns requiring lipophilic, electron-deficient heterocycles with defined spatial orientation.
5-(Trifluoromethyl)-1H-indole-3-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient access to indole-based scaffolds prevalent in medicinal chemistry. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the aldehyde functionality facilitates reductive amination, Wittig reactions, and condensation with amines or hydrazines. Bench-stable and readily purified by flash chromatography, it functions effectively in standard coupling and functionalization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: