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Structure of 475060-42-5
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N-Methylpiperidine-3-carboxamide hydrochloride delivers a rigid, electron-rich piperidine scaffold with a strategically positioned amide and methylated nitrogen. This combination enhances solubility and metabolic stability while maintaining favorable conformational restraint for target engagement in medicinal chemistry applications.
N-Methylpiperidine-3-carboxamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles and peptide-like scaffolds. Its amide functionality offers enhanced metabolic stability and improved membrane permeability compared to parent amides. The piperidine core provides a rigid, conformationally constrained scaffold with favorable pharmacokinetic properties. Bench-stable and readily purified by recrystallization or ion-exchange chromatography, it functions effectively in standard coupling reactions and transition-metal-catalyzed transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: