5-Chloro-2-methoxybenzenesulfonyl chloride

Name: 5-Chloro-2-methoxybenzenesulfonyl chloride
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CAS No. 22952-32-5
Cat. No. CS-W012798
Purity≥97%
MDL No.MFCD00052959

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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5-Chloro-2-methoxybenzenesulfonyl chloride|CS-W012798

Structure of 22952-32-5

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Description

5-Chloro-2-methoxybenzenesulfonyl chloride features a sulfonyl chloride group flanked by electron-withdrawing chlorine and electron-donating methoxy substituents, enabling selective electrophilic functionalization. This balance enhances reactivity in amide and sulfonamide synthesis while maintaining stability under standard bench conditions.

Application

5-Chloro-2-methoxybenzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of a sulfonamide moiety in medicinal chemistry and agrochemical synthesis. Its ortho-methoxy and meta-chloro substituents enhance reactivity while maintaining bench stability, enabling clean transformations with amines and alcohols under mild conditions. The compound exhibits excellent functional group tolerance and facilitates straightforward purification, making it ideal for building complex heterocyclic scaffolds and targeted API intermediates.

General Information

CAS No. 22952-32-5
Cat. No. CS-W012798
Purity ≥97%
MDL No. MFCD00052959
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆Cl₂O₃S
Molecular Weight 241.08
Synonym(s) 5-chloro-2-methoxybenzene-1-sulfonyl chloride
SMILES O=S(C1=CC(Cl)=CC=C1OC)(Cl)=O

Computational Chemistry Data

TPSA 43.37
LogP 2.2761
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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5-Chloro-2-methoxybenzenesulfonyl chloride

CAS No. 22952-32-5

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