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Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate

  • CAS No. 4815-24-1

  • Cat. No. CS-W015637
  • Purity≥97%
  • MDL No.MFCD00085051

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate|CS-W015637

Structure of 4815-24-1

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General Information

  • CAS No. 4815-24-1
  • Cat. No. CS-W015637
  • Purity ≥97%
  • MDL No. MFCD00085051
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃NO₂S
  • Molecular Weight None
  • Synonym(s) 2-Amino-4,5-dimethylthiophene-3-carboxylic Acid Ethyl Ester
  • SMILES CCOC(=O)C1=C(N)SC(C)=C1C

Description

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate features a sterically hindered thiophene core with complementary electron-rich amine and ester functionalities. This bench-stable scaffold integrates readily into heterocyclic synthesis, enabling efficient access to functionalized thienyl building blocks for medicinal chemistry and materials applications.

Application

Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate serves as a versatile heterocyclic building block for the synthesis of substituted thiophenes and fused polycycles. The amino and ester functionalities enable sequential transformations, including coupling reactions, cyclizations, and derivatization under standard conditions. Its bench-stable nature and compatibility with diverse reaction environments facilitate efficient access to complex scaffolds relevant in medicinal chemistry and materials science.

Synthesis

  • Route1
    • null|null
      105-56-6
    • null|null
      78-93-3
    • ~91%
    • In-stock
      Ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate|CS-W015637
      4815-24-1

    References

    • Moeinpour, Farid; Dorostkar, Nadieh; Vafaei, Majid Synthetic Communications, 2012 , vol. 42, # 16 p. 2367 - 2374

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   2.12384
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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