4-Amino-6-chloro-5-methoxypyrimidine

Name: 4-Amino-6-chloro-5-methoxypyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 5018-41-7
Cat. No. CS-0045688
Purity≥97%
MDL No.MFCD07787635

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Amino-6-chloro-5-methoxypyrimidine|CS-0045688

Structure of 5018-41-7

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Description

4-Amino-6-chloro-5-methoxypyrimidine features a strategically positioned amino group and methoxy substituent on a pyrimidine core, enabling selective coupling reactions in medicinal chemistry. The chloro handle facilitates nucleophilic substitution, while the electron-donating methoxy group enhances solubility and modulates reactivity under standard conditions. This scaffold serves as a key building block for kinase inhibitors and antiviral agents.

Application

4-Amino-6-chloro-5-methoxypyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its amino and chloro groups facilitate sequential functionalization via nucleophilic substitution and coupling reactions. The methoxy group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—key advantages for high-throughput synthesis and API development workflows.

General Information

CAS No. 5018-41-7
Cat. No. CS-0045688
Purity ≥97%
MDL No. MFCD07787635
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆ClN₃O
Molecular Weight 159.58
Synonym(s) 6-Chloro-5-MethoxypyriMidin-4-ylaMine
SMILES COC1=C(Cl)N=CN=C1N

Computational Chemistry Data

TPSA 61.03
LogP 0.7208
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Amino-6-chloro-5-methoxypyrimidine

CAS No. 5018-41-7

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