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CS-W001157 4
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(2,6-Difluorophenyl)hydrazine hydrochloride

  • CAS No. 502496-26-6

  • Cat. No. CS-W021529
  • Purity≥95%
  • MDL No.MFCD03094169

*For research and further manufacturing use only, not for direct human use.

(2,6-Difluorophenyl)hydrazine hydrochloride|CS-W021529

Structure of 502496-26-6

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General Information

  • CAS No. 502496-26-6
  • Cat. No. CS-W021529
  • Purity ≥95%
  • MDL No. MFCD03094169
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClF₂N₂
  • Molecular Weight 180.58
  • Synonym(s) 2,6-Difluorophenylhydrazine hydrochloride
  • SMILES NNC1=C(F)C=CC=C1F.[H]Cl

Description

(2,6-Difluorophenyl)hydrazine hydrochloride features a fluorinated aromatic scaffold that enhances metabolic stability and modulates electronic properties. This bench-stable derivative enables direct incorporation into azo and triazine scaffolds, offering improved solubility in polar reaction media. The hydrazinium salt form ensures high reactivity in coupling processes without requiring additional activation.

Application

(2,6-Difluorophenyl)hydrazine hydrochloride serves as a key building block for the synthesis of fluorinated heterocycles and azo dyes. Its difluorophenyl moiety enhances metabolic stability and modulates electronic properties in target molecules. The hydrazine functionality enables efficient cyclization reactions, including formation of imidazoles, triazoles, and pyrazoles under mild conditions. Bench-stable and readily purified by recrystallization, it exhibits broad functional group tolerance in standard coupling and condensation protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.6722
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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