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Structure of 50824-04-9
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4-Bromo-2-(trifluoromethyl)phenol features a trifluoromethyl group ortho to a phenolic hydroxyl, enhancing electron-withdrawal and metabolic stability. The bromine substituent at the para position enables direct functionalization via palladium-catalyzed coupling. This combination delivers high reactivity in cross-coupling and electrophilic substitution reactions.
4-Bromo-2-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized aromatic systems. Its bromine and phenolic hydroxyl groups provide orthogonal reactivity for palladium-catalyzed cross-couplings and electrophilic substitutions. The trifluoromethyl group enhances metabolic stability and lipophilicity, making this scaffold valuable for drug discovery. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: