(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid

Name: (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 511272-53-0
Cat. No. CS-0062191
Purity≥97%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid|CS-0062191

Structure of 511272-53-0

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Description

Fmoc-(R)-3-Amino-3-(3-chlorophenyl)-propionic acid is a bench-stable, moisture-tolerant building block for peptide synthesis. This chiral amino acid features a para-chlorinated aromatic side chain that enhances lipophilicity and metabolic stability. The Fmoc group enables efficient N-terminal protection during solid-phase peptide coupling workflows.

Application

Fmoc-(R)-3-Amino-3-(3-chlorophenyl)-propionic acid serves as a valuable building block for the synthesis of peptidomimetics and bioactive scaffolds. Its Fmoc-protected amine enables efficient solid-phase peptide synthesis, while the pendant 3-chlorophenyl group provides steric and electronic modulation. The molecule exhibits excellent bench stability, facilitates straightforward purification, and tolerates a broad range of reaction conditions, making it ideal for iterative coupling and heterocycle formation in medicinal chemistry workflows.

General Information

CAS No. 511272-53-0
Cat. No. CS-0062191
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀ClNO₄
Molecular Weight 421.87
Synonym(s) Fmoc-R-3-Amino-3-(3-chloro-phenyl)-propionic acid
SMILES O=C(O)C[C@H](C1=CC(Cl)=CC=C1)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Computational Chemistry Data

TPSA 75.63
LogP 5.3945
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid

CAS No. 511272-53-0

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