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Structure of 52107-68-3
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5-Iodo-2-methylbenzonitrile features a sterically hindered aromatic core with complementary electron-withdrawing nitrile and iodine substituents. This combination enables efficient cross-coupling transformations under standard conditions, delivering functionalized heterocycles with high regiocontrol. The bench-stable compound integrates readily into synthetic sequences requiring halogen-directed C–C bond formation.
5-Iodo-2-methylbenzonitrile serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki and Stille reactions due to its stable aryl iodide functionality and electron-withdrawing nitrile group. The methyl substituent provides steric and electronic modulation, enhancing regioselectivity in subsequent transformations. Its bench-stable nature and compatibility with standard catalytic systems make it ideal for constructing complex heterocycles and pharmaceutical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: