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CS-W001157 4
Total: USD 88.00

(E)-2-Phenylethylenesulfonyl chloride

  • CAS No. 52147-97-4

  • Cat. No. CS-0117008
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

(E)-2-Phenylethylenesulfonyl chloride|CS-0117008

Structure of 52147-97-4

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Description

(E)-2-Phenylethylenesulfonyl chloride features a conjugated vinyl sulfone moiety enabling direct incorporation into Michael acceptor-based synthetic sequences. The sulfonyl chloride group provides high reactivity toward nucleophiles, facilitating rapid functionalization under mild conditions. This compound serves as a stable, bench-ready electrophile for constructing complex organic architectures in medicinal chemistry and materials synthesis.

Application

(E)-2-Phenylethylenesulfonyl chloride serves as a versatile electrophilic sulfonylating agent, enabling efficient introduction of sulfonate groups under mild conditions. Its conjugated vinyl sulfone structure enhances stability and facilitates selective reactions with nucleophiles such as amines and thiols, making it valuable for synthesizing sulfonamide and sulfonate derivatives in medicinal chemistry workflows. The compound exhibits good bench stability and is compatible with common functional groups, supporting straightforward purification and integration into multi-step syntheses.

General Information

  • CAS No. 52147-97-4
  • Cat. No. CS-0117008
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClO₂S
  • Molecular Weight 202.66
  • Synonym(s) β-STYRENE SULFONYL CHLORIDE
  • SMILES O=S(/C=C/C1=CC=CC=C1)(Cl)=O

Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.2259
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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