2,3-Dihydro-1H-indene-5-sulfonyl chloride

Name: 2,3-Dihydro-1H-indene-5-sulfonyl chloride
Brand: ChemScene
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CAS No. 52205-85-3
Cat. No. CS-0208425
Molecule weight216.68
Purity≥97%
MDL No.MFCD05237217

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2,3-Dihydro-1H-indene-5-sulfonyl chloride|CS-0208425

Structure of 52205-85-3

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General Information

CAS No. 52205-85-3
Cat. No. CS-0208425
Purity ≥97%
MDL No. MFCD05237217
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉ClO₂S
Molecular Weight 216.68
Synonym(s) Indane-5-Sulfonyl Chloride
SMILES C1CC2=CC=C(C=C2C1)S(=O)(=O)Cl

Description

This sulfonyl chloride derivative features a rigid, aromatic-indene scaffold that enhances reactivity and stability. The 5-sulfonyl chloride group enables efficient coupling reactions in synthetic routes to functionalized heterocycles and bioactive molecules. Bench-stable under standard conditions, it integrates seamlessly into pharmaceutical intermediates and materials chemistry workflows.

Application

2,3-Dihydro-1H-indene-5-sulfonyl chloride serves as a versatile sulfonyl chloride building block for the synthesis of sulfonamide-containing compounds. Its reactive sulfonyl chloride group enables efficient coupling with amines under mild conditions, facilitating access to pharmaceutically relevant scaffolds. The rigid, hydrophobic indene core provides structural diversity and enhanced metabolic stability, making it valuable in medicinal chemistry campaigns targeting kinase inhibitors and other bioactive molecules.

Synthesis

Route1
- In-stock
  
  496-11-7
- ~%
- In-stock
  
  52205-85-3
References
- Bock, Hans; Rittmeyer, Peter Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 68, # 1-4 p. 261 - 292
Route2
- 7790-94-5
- In-stock
  
  496-11-7
- ~%
- In-stock
  
  52205-85-3
References
- Eli Lilly and Company, Eli Lilly and Company Patent: WO2004/48329 A1, 2004 ; Location in patent: Page 13 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 34.14
LogP 2.1028
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,3-Dihydro-1H-indene-5-sulfonyl chloride

CAS No. 52205-85-3

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