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CS-W001157 4
Total: USD 88.00

5-Methoxypyrazin-2-amine

  • CAS No. 54013-07-9

  • Cat. No. CS-W019181
  • Purity≥95%
  • MDL No.MFCD09909647

*For research and further manufacturing use only, not for direct human use.

5-Methoxypyrazin-2-amine|CS-W019181

Structure of 54013-07-9

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General Information

  • CAS No. 54013-07-9
  • Cat. No. CS-W019181
  • Purity ≥95%
  • MDL No. MFCD09909647
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃O
  • Molecular Weight 125.13
  • Synonym(s) 5-Methoxypyrazin-2-amin
  • SMILES NC1=NC=C(N=C1)OC

Description

5-Methoxypyrazin-2-amine is a heterocyclic amine featuring a pyrazine core with a methoxy group at the 5-position and an amino substituent at the 2-position. This combination imparts enhanced solubility and electronic modulation, enabling its use in medicinal chemistry scaffolds and as a building block for functionalized nitrogen-containing compounds.

Application

5-Methoxypyrazin-2-amine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its pyrazine core provides a rigid, electron-deficient scaffold ideal for metal coordination and π-stacking interactions. The ortho-amino and methoxy substituents enable sequential functionalization via coupling reactions, nucleophilic substitution, or transition-metal-catalyzed transformations. Bench-stable and amenable to purification by chromatography or recrystallization, it functions effectively in multistep syntheses of bioactive molecules and advanced ligands.

Synthesis

  • Route1
    • null|null
      124-41-4
    • In-stock
      5-Chloropyrazin-2-amine|CS-W007882
      33332-29-5
    • ~67%
    • In-stock
      5-Methoxypyrazin-2-amine|CS-W019181
      54013-07-9

    References

    • WO2013/68458 A1, ; Page/Page column 45 ;
  • Route2
    • In-stock
      2-Amino-5-bromopyrazine|CS-W009264
      59489-71-3
    • null|null
      124-41-4
    • ~58%
    • In-stock
      5-Methoxypyrazin-2-amine|CS-W019181
      54013-07-9

    References

    • Journal of Chemical Research, , # 11 p. 747 - 749

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.03
  • LogP   0.0674
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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