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Structure of 54189-82-1
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6-Chloro-N-methylnicotinamide features a chlorinated pyridine ring paired with a methylnicotinamide group, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables direct incorporation into bioactive scaffolds, particularly in kinase inhibitor design and medicinal chemistry lead optimization. The molecule exhibits favorable solubility and bench-stability under standard conditions.
6-Chloro-N-methylnicotinamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation into heterocyclic scaffolds via standard coupling and functionalization reactions. Its chloro group facilitates palladium-catalyzed cross-coupling, while the N-methylpyridine moiety offers enhanced metabolic stability and favorable pharmacokinetic properties. The compound exhibits excellent bench stability and compatibility with common purification methods, making it ideal for high-throughput synthesis and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: