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CS-W001157 4
Total: USD 88.00

4-Chloropicolinic acid

  • CAS No. 5470-22-4

  • Cat. No. CS-D1470
  • Purity≥97%
  • MDL No.MFCD00191400

*For research and further manufacturing use only, not for direct human use.

4-Chloropicolinic acid|CS-D1470

Structure of 5470-22-4

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General Information

  • CAS No. 5470-22-4
  • Cat. No. CS-D1470
  • Purity ≥97%
  • MDL No. MFCD00191400
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClNO₂
  • Molecular Weight 157.55
  • Synonym(s) 4-Chloropyridine-2-carboxylic acid; NSC 26285; 4-chloropyridine-2-carboxylate
  • SMILES O=C(C1=NC=CC(Cl)=C1)O

Description

4-Chloropicolinic acid is a bench-stable, electron-deficient heterocyclic carboxylic acid featuring a chlorine substituent at the pyridine ring's 4-position. This configuration enhances its utility in cross-coupling reactions and as a building block for bioactive compounds. The para-chloro group facilitates further functionalization while maintaining structural integrity under standard conditions.

Application

4-Chloropicolinic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via coupling reactions. Its ortho-chloro substituent enhances electrophilicity for nucleophilic substitution and facilitates transition-metal-catalyzed functionalization. The carboxylic acid group provides direct handle for amide formation, esterification, or derivatization, supporting modular synthesis workflows. Bench-stable and readily purified, it functions reliably in standard organic transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.4332
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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