CRBN ligand-9

Name: CRBN ligand-9
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 55003-81-1
Cat. No. CS-0453666
Purity≥98%
MDL No.MFCD30188076

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

CRBN ligand-9 features a potent, bench-stable imidazolone scaffold that selectively engages the E3 ubiquitin ligase complex. This compound integrates efficiently into targeted protein degradation workflows, enabling robust recruitment of disease-relevant substrates for ubiquitination and subsequent proteasomal clearance.

Application

CRBN ligand-9 serves as a well-characterized cereblon-binding moiety enabling targeted protein degradation via the E3 ubiquitin ligase complex. It functions as a key pharmacophore in PROTAC design, facilitating selective ubiquitination and proteasomal degradation of disease-relevant targets. The compound exhibits robust bench stability, favorable solubility, and compatibility with standard coupling reactions, supporting efficient synthesis of bifunctional degraders.

General Information

CAS No. 55003-81-1
Cat. No. CS-0453666
Purity ≥98%
MDL No. MFCD30188076
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₉N₃O₆
Molecular Weight 303.23
Synonym(s) None
SMILES O=C1NC(CCC1N2C(C3=CC=C(C=C3C2=O)[N+](=O)[O-])=O)=O

Computational Chemistry Data

TPSA 129.37
LogP -0.8122
H_Acceptors 8
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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CRBN ligand-9

CAS No. 55003-81-1

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