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Structure of 552331-49-4
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tert-Butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate features a brominated indazole core with a methyl group at the 3-position and a tert-butyl ester handle. This scaffold enables direct functionalization in late-stage diversification, particularly in cross-coupling reactions. The tert-butyl ester offers stability under basic conditions while permitting straightforward deprotection to the carboxylic acid.
tert-Butyl 5-bromo-3-methyl-1H-indazole-1-carboxylate serves as a versatile building block for the synthesis of substituted indazole scaffolds. The bromo group enables palladium-catalyzed cross-coupling reactions, while the tert-butyl ester offers stability and convenient deprotection under mild acidic conditions. Its methyl substituent at C3 provides regiocontrol in further functionalization, making it well-suited for medicinal chemistry campaigns targeting kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: