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CS-W001157 4
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1-Ethyl-1H-pyrazol-3-amine

  • CAS No. 55361-49-4

  • Cat. No. CS-0122652
  • Purity≥98%
  • MDL No.MFCD03422571

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-1H-pyrazol-3-amine|CS-0122652

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General Information

  • CAS No. 55361-49-4
  • Cat. No. CS-0122652
  • Purity ≥98%
  • MDL No. MFCD03422571
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃
  • Molecular Weight 111.15
  • Synonym(s) 1-ethylpyrazol-3-amine
  • SMILES NC1=NN(CC)C=C1

Description

1-Ethyl-1H-pyrazol-3-amine features a pyrazole core with an ethyl substituent at the 1-position and a primary amine at the 3-position, offering enhanced solubility and reactivity in synthetic transformations. This bench-stable heterocycle integrates readily into medicinal chemistry scaffolds, serving as a key building block for bioactive molecule development.

Application

1-Ethyl-1H-pyrazol-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based scaffolds through standard coupling and functionalization reactions. The amine group facilitates conjugation with electrophiles, while the ethyl substituent enhances solubility and metabolic stability. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for synthesizing targeted heterocyclic compounds in API development.

Synthesis

  • Route1

    References

    • US2008/21032 A1, ; Page/Page column 44 ; US 20080021032 A1
  • Route2
    • In-stock
      Ethylhydrazine oxalate|CS-W004907
      6629-60-3
    • null|null
      920-37-6
    • ~83%
    • In-stock
      1-Ethyl-1H-pyrazol-3-amine|CS-0122652
      55361-49-4

    References

    • WO2005/60970 A1, ; Page/Page column 160 ; WO 2005/060970 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.4852
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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