2-Chloro-5-hydroxybenzoic acid

Name: 2-Chloro-5-hydroxybenzoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 56961-30-9
Cat. No. CS-W007855
Purity≥97%
MDL No.MFCD04038818

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-hydroxybenzoic acid|CS-W007855

Structure of 56961-30-9

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General Information

CAS No. 56961-30-9
Cat. No. CS-W007855
Purity ≥97%
MDL No. MFCD04038818
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClO₃
Molecular Weight 172.57
Synonym(s) 2-Chloro-5-hydroxybenzoicacid
SMILES O=C(O)C1=CC(O)=CC=C1Cl

Description

2-Chloro-5-hydroxybenzoic acid features a hydroxyl group positioned ortho to a carboxylic acid and flanked by a chlorine substituent, enabling diverse functionalization in medicinal chemistry. This electron-deficient aromatic scaffold supports coupling reactions under mild conditions and offers enhanced solubility compared to non-hydroxylated analogs.

Application

2-Chloro-5-hydroxybenzoic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling direct functionalization at the phenolic hydroxyl and carboxylic acid sites. Its ortho-chloro substituent facilitates palladium-catalyzed cross-coupling reactions, while the hydroxyl group supports derivatization via esterification or ether formation. The compound exhibits good bench stability and is amenable to standard purification methods, making it well-suited for multi-step synthetic sequences in medicinal chemistry and process development.

Synthesis

Route1
- In-stock
  
  89-54-3
- ~70%
- In-stock
  
  56961-30-9
References
- Gunosewoyo, Hendra; Guo, Jun Liu; Bennett, Maxwell R.; Coster, Mark J.; Kassiou, Michael Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 13 p. 3720 - 3723
Route2
- In-stock
  
  99-06-9
- ~%
- In-stock
  
  51786-10-8
- In-stock
  
  56961-30-9
References
- Journal of the American Chemical Society, , vol. 68, p. 575 Journal of the American Chemical Society, , vol. 73, p. 2347 Roczniki Chemii, , vol. 10, p. 761,765,771 Chem. Zentralbl., , vol. 102, # I p. 1427
Route3
- 17005-59-3
- ~%
- In-stock
  
  56961-30-9
References
- Tetrahedron, , vol. 61, # 13 p. 3393 - 3401

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 57.53
LogP 1.7438
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-5-hydroxybenzoic acid

CAS No. 56961-30-9

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