3-Bromoimidazo[1,2-a]pyrazine

Name: 3-Bromoimidazo[1,2-a]pyrazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 57948-41-1
Cat. No. CS-W003278
Purity≥97%
MDL No.MFCD06245372

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Bromoimidazo[1,2-a]pyrazine|CS-W003278

Structure of 57948-41-1

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General Information

CAS No. 57948-41-1
Cat. No. CS-W003278
Purity ≥97%
MDL No. MFCD06245372
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrN₃
Molecular Weight 198.02
Synonym(s) 3-Bromimidazo[1,2-a]pyrazin
SMILES Brc1cnc2n1ccnc2

Description

3-Bromoimidazo[1,2-a]pyrazine is a heterocyclic bromo compound featuring a fused imidazo[1,2-a]pyrazine core. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and advanced materials. The bromine substituent provides a reactive handle for palladium-catalyzed transformations under standard conditions.

Application

3-Bromoimidazo[1,2-a]pyrazine serves as a versatile heterocyclic building block for medicinal chemistry and catalytic cross-coupling applications. The bromine substituent enables reliable Suzuki-Miyaura and Negishi couplings, facilitating the construction of biologically relevant scaffolds. Its stability under standard reaction conditions and compatibility with diverse functional groups make it a practical choice for modular synthesis in drug discovery workflows.

Synthesis

Route1
- In-stock
  
  274-79-3
- ~99%
- In-stock
  
  57948-41-1
References
- Goodacre, Simon Charles; Hallett, David James; Street, Leslie Joseph Patent: US2004/19057 A1, 2004 ; Location in patent: Page/Page column 9 ;
Route2
- In-stock
  
  274-79-3
- ~4%
- In-stock
  
  63744-21-8
- In-stock
  
  87597-26-0
- In-stock
  
  57948-41-1
References
- Journal of Medicinal Chemistry, , vol. 27, # 2 p. 206 - 212

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 30.19
LogP 1.4918
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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3-Bromoimidazo[1,2-a]pyrazine

CAS No. 57948-41-1

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