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CS-W001157 4
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4,5-Dimethylpyridin-2-amine

  • CAS No. 57963-11-8

  • Cat. No. CS-0153165
  • Purity≥98%
  • MDL No.MFCD09027052

*For research and further manufacturing use only, not for direct human use.

4,5-Dimethylpyridin-2-amine|CS-0153165

Structure of 57963-11-8

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General Information

  • CAS No. 57963-11-8
  • Cat. No. CS-0153165
  • Purity ≥98%
  • MDL No. MFCD09027052
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) 2-AMINO-4,5-DIMETHYLPYRIDINE
  • SMILES NC1=NC=C(C)C(C)=C1

Description

4,5-Dimethylpyridin-2-amine features a pyridine core with methyl groups at the 4 and 5 positions, enhancing electron density at the nitrogen lone pair. This substitution pattern improves basicity and nucleophilicity compared to unsubstituted pyridine derivatives. The compound serves as a robust ligand in transition metal catalysis and integrates readily into functionalized heterocycles. Its bench-stable nature supports reliable use in synthetic workflows.

Application

4,5-Dimethylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds via standard coupling and functionalization reactions. Its electron-rich heterocyclic core exhibits favorable stability and compatibility with common synthetic protocols, facilitating efficient derivatization for target-oriented synthesis. The molecule functions effectively as a ligand in transition metal catalysis and supports ortho-directed metallation due to its nitrogen positioning.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.28064
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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