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Structure of 39919-70-5
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6-(tert-Butyl)pyridin-3-amine features a sterically hindered tert-butyl group positioned para to a primary amine on the pyridine ring, enhancing solubility and stability. This electronic and steric profile enables efficient coupling in transition metal catalysis and facilitates incorporation into functionalized ligands and pharmaceutical intermediates under standard conditions.
6-(tert-Butyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its tert-butyl group enhances solubility and steric shielding, while the pyridine nitrogen and primary amine offer orthogonal functionalization sites. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthesis and scale-up in API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P280-P302+P352
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Lot numbers can be found on the outside label of a product: