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CS-W001157 4
Total: USD 88.00

H-Serinol(Bzl)

  • CAS No. 58577-87-0

  • Cat. No. CS-W017151
  • Purity≥98%
  • MDL No.MFCD00235943

*For research and further manufacturing use only, not for direct human use.

H-Serinol(Bzl)|CS-W017151

Structure of 58577-87-0

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General Information

  • CAS No. 58577-87-0
  • Cat. No. CS-W017151
  • Purity ≥98%
  • MDL No. MFCD00235943
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₂
  • Molecular Weight 181.24
  • Synonym(s) (R)-2-Amino-3-(benzyloxy)propan-1-ol
  • SMILES OC[C@@H](N)COCC1=CC=CC=C1

Description

H-Serinol(Bzl) features a benzyl-protected serinol backbone, offering a stable, moisture-tolerant platform for peptide and glycomimetic synthesis. This protected amino alcohol integrates seamlessly into complex molecular architectures, enabling efficient coupling under standard conditions while maintaining orthogonal reactivity for downstream transformations.

Application

H-Serinol(Bzl) serves as a versatile chiral building block for the synthesis of bioactive heterocycles and peptide-like scaffolds. Its benzyl-protected hydroxyl groups enable orthogonal deprotection strategies, while the primary amine facilitates conjugation reactions. The molecule exhibits excellent bench stability and compatibility with standard coupling protocols, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Danklmaier, Johann; Hoenig, Helmut Liebigs Annalen der Chemie, 1988 , p. 851 - 854
  • Route2
    • null|null
      194861-65-9
    • ~%
    • In-stock
      H-Serinol(Bzl)|CS-W017151
      58577-87-0

    References

    • WO2006/83440 A2, ; Page/Page column 142 ;
  • Route3
    • null|null
      1336-21-6
    • null|null
      60-29-7
    • In-stock
      H-Ser(Bzl)-OH|CS-W008308
      4726-96-9
    • ~%
    • In-stock
      H-Serinol(Bzl)|CS-W017151
      58577-87-0

    References

    • US6149890 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.48
  • LogP   0.5228
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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