Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate

Name: Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate
Brand: ChemScene
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CAS No. 6214-46-6
Cat. No. CS-W022646
Purity≥97%
MDL No.MFCD11656636

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Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate|CS-W022646

Structure of 6214-46-6

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Description

Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate features a pyrimidine core functionalized with a hydroxyl group and an acetyl ester side chain, enabling direct incorporation into heterocyclic synthesis. This bench-stable intermediate supports efficient derivatization in medicinal chemistry workflows, particularly for nucleoside analogs and kinase inhibitors.

Application

Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate serves as a versatile building block for pyrimidine-based heterocycles, enabling straightforward functionalization at the C5 position. The pendant hydroxyl group facilitates derivatization via esterification or ether formation, while the ethyl acrylate moiety supports palladium-catalyzed cross-coupling reactions. Bench-stable and readily purified by column chromatography, it functions effectively in multi-step synthesis of kinase inhibitors and other medicinal chemistry scaffolds.

General Information

CAS No. 6214-46-6
Cat. No. CS-W022646
Purity ≥97%
MDL No. MFCD11656636
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀N₂O₃
Molecular Weight 182.18
Synonym(s) ETHYL2-(4-HYDROXYPYRIMIDIN-5-YL)ACETATE
SMILES CCOC(=O)CC1=C(O)N=CN=C1

Computational Chemistry Data

TPSA 72.31
LogP 0.2878
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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Ethyl 2-(4-hydroxypyrimidin-5-yl)acetate

CAS No. 6214-46-6

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