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CS-W001157 4
Total: USD 88.00

1-Cyclopropylpiperidin-4-amine

  • CAS No. 62813-02-9

  • Cat. No. CS-0100626
  • Molecule weight140.23
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropylpiperidin-4-amine|CS-0100626

Structure of 62813-02-9

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General Information

  • CAS No. 62813-02-9
  • Cat. No. CS-0100626
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂
  • Molecular Weight 140.23
  • Synonym(s) 4-Amino-1-cyclopropylpiperidine, (4-Aminopiperidin-1-yl)cyclopropane
  • SMILES NC1CCN(C2CC2)CC1

Description

1-Cyclopropylpiperidin-4-amine features a cyclopropyl group attached to a piperidine ring, delivering enhanced metabolic stability and improved membrane permeability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for CNS-targeted therapeutics and kinase inhibitors.

Application

1-Cyclopropylpiperidin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its tertiary amine functionality offers favorable solubility and metabolic stability, while the cyclopropyl group enhances conformational rigidity and lipophilic interactions. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, facilitating efficient synthesis of targeted compounds through straightforward functionalization.

Synthesis

  • Route1
    • null|null
      1001345-77-2
    • ~64%
    • In-stock
      1-Cyclopropylpiperidin-4-amine|CS-0100626
      62813-02-9

    References

    • ASTRAZENECA AB Patent: US2008/9482 A1, 2008 ; Location in patent: Page/Page column 107 ; US 20080009482 A1
  • Route2
    • null|null
      62813-01-8
    • null|null
      101752-05-0
    • ~%
    • In-stock
      1-Cyclopropylpiperidin-4-amine|CS-0100626
      62813-02-9

    References

    • US4005208 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.5719
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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