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CS-W001157 4
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(2-(Difluoromethoxy)pyridin-4-yl)methanamine hydrochloride

  • CAS No. 943843-27-4

  • Cat. No. CS-0119772
  • Molecule weight210.61
  • Purity≥98%
  • MDL No.MFCD21605147

*For research and further manufacturing use only, not for direct human use.

(2-(Difluoromethoxy)pyridin-4-yl)methanamine hydrochloride|CS-0119772

Structure of 943843-27-4

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General Information

  • CAS No. 943843-27-4
  • Cat. No. CS-0119772
  • Purity ≥98%
  • MDL No. MFCD21605147
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉ClF₂N₂O
  • Molecular Weight 210.61
  • Synonym(s) [2-(difluoromethoxy)pyridin-4-yl]methanamine,hydrochloride
  • SMILES NCC1=CC(OC(F)F)=NC=C1.[H]Cl

Description

This difluoromethoxy-substituted pyridylmethanamine hydrochloride features a bench-stable, moisture-tolerant scaffold with enhanced solubility in aqueous and polar organic media. The para-difluoromethoxy group imparts strong electron-withdrawing character, enabling efficient coupling reactions and facilitating incorporation into bioactive molecules for medicinal chemistry applications.

Application

(2-(Difluoromethoxy)pyridin-4-yl)methanamine hydrochloride serves as a valuable building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. The difluoromethoxy group imparts enhanced metabolic stability and modulates lipophilicity, while the primary amine functionality facilitates straightforward derivatization via amide coupling, reductive amination, or electrophilic substitution. Its crystalline hydrochloride salt ensures excellent bench stability, ease of handling, and compatibility with standard purification protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.5635
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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