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Structure of 943843-27-4
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This difluoromethoxy-substituted pyridylmethanamine hydrochloride features a bench-stable, moisture-tolerant scaffold with enhanced solubility in aqueous and polar organic media. The para-difluoromethoxy group imparts strong electron-withdrawing character, enabling efficient coupling reactions and facilitating incorporation into bioactive molecules for medicinal chemistry applications.
(2-(Difluoromethoxy)pyridin-4-yl)methanamine hydrochloride serves as a valuable building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. The difluoromethoxy group imparts enhanced metabolic stability and modulates lipophilicity, while the primary amine functionality facilitates straightforward derivatization via amide coupling, reductive amination, or electrophilic substitution. Its crystalline hydrochloride salt ensures excellent bench stability, ease of handling, and compatibility with standard purification protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: