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CS-W001157 4
Total: USD 88.00

2-Amino-5-fluorobenzamide

  • CAS No. 63069-49-8

  • Cat. No. CS-W005552
  • Purity≥97%
  • MDL No.MFCD03428522

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-fluorobenzamide|CS-W005552

Structure of 63069-49-8

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General Information

  • CAS No. 63069-49-8
  • Cat. No. CS-W005552
  • Purity ≥97%
  • MDL No. MFCD03428522
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FN₂O
  • Molecular Weight 154.14
  • Synonym(s) Benzamide,2-amino-5-fluoro-
  • SMILES NC(C1=C(C=CC(F)=C1)N)=O

Description

2-Amino-5-fluorobenzamide features a fluorinated aromatic ring paired with dual amine and amide functionalities, enabling integration into pharmaceutical scaffolds. The para-fluoro substitution enhances metabolic stability while the amino group facilitates conjugation reactions under standard conditions. This compound serves as a key intermediate in the synthesis of bioactive molecules requiring electron-deficient aryl linkages.

Application

2-Amino-5-fluorobenzamide serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated heterocycles and bioactive scaffolds. Its ortho-amino and amide functionalities offer complementary reactivity for coupling reactions, cyclizations, and derivatization under standard conditions. The molecule exhibits good bench stability and facilitates efficient purification, supporting its use in multi-step syntheses and API development workflows.

Synthesis

  • Route1

    References

    • Johnson, Neil W.; Bryan, Deborah L. Patent: US2008/182852 A1, 2008 ; Location in patent: Page/Page column 28 ; US 20080182852 A1
  • Route2

    References

    • BAYER PHARMACEUTICALS CORPORATION Patent: WO2006/34491 A2, 2006 ; Location in patent: Page/Page column 43 ; WO 2006/034491 A2
  • Route3

    References

    • WO2006/28904 A1, ; Page/Page column 113-114 ; WO 2006/028904 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   69.11
  • LogP   0.5068
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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