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Structure of 6358-77-6
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5-Bromo-2-methoxyaniline features a bromine substituent at the 5-position and a methoxy group at the 2-position, conferring enhanced electron density and improved solubility in polar organic solvents. This aniline derivative serves as a key intermediate in the synthesis of pharmaceuticals and functional dyes, offering high reactivity in coupling reactions under standard conditions.
5-Bromo-2-methoxyaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted heterocycles via Pd-catalyzed cross-coupling reactions. The bromo group facilitates reliable Suzuki, Stille, or Negishi coupling, while the methoxy functionality offers moderate electron donation and orthogonal reactivity. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthetic campaigns requiring functional group tolerance and predictable regiochemistry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H317-H401
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P363-P391-P501
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Lot numbers can be found on the outside label of a product: