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Structure of 63762-79-8
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2-Fluoro-5-methylphenol features a fluorine atom at the ortho position and a methyl group at the para position relative to the phenolic hydroxyl, creating a uniquely electron-deficient aromatic system. This combination imparts enhanced reactivity in electrophilic substitution and improved metabolic stability, making it valuable for pharmaceutical intermediates and agrochemical synthesis.
2-Fluoro-5-methylphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-fluoro and meta-methyl substituents provide directed functionalization potential and enhanced metabolic stability. The compound exhibits good bench stability, facilitates straightforward purification, and functions effectively in Suzuki-Miyaura and Ullmann-type transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: