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Structure of 63812-15-7
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2-Fluoro-2-methylpropanoic acid is a sterically hindered, bench-stable fluorinated carboxylic acid featuring a trifluoromethyl-like electronic profile. This structure enables direct incorporation into bioactive scaffolds, particularly in medicinal chemistry where metabolic stability and lipophilicity are critical. The molecule resists decarboxylation under standard conditions and pairs effectively with nucleophilic reagents in coupling reactions.
2-Fluoro-2-methylpropanoic acid serves as a valuable building block for fluorinated aliphatic scaffolds, enabling the synthesis of bioactive molecules through nucleophilic substitution or decarboxylation pathways. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient incorporation into medicinal chemistry libraries. The geminal fluoromethyl motif provides enhanced metabolic stability and modulates lipophilicity, making it a practical choice for lead optimization in drug discovery.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H300-H310-H314-H318-H330
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Precautionary Statements : P260-P262-P264-P270-P271-P280-P284-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P361+P364-P363-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: