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CS-W001157 4
Total: USD 88.00

3-Amino-5-methoxy-pyridine

  • CAS No. 64436-92-6

  • Cat. No. CS-W003621
  • Purity≥98%
  • MDL No.MFCD09701369

*For research and further manufacturing use only, not for direct human use.

3-Amino-5-methoxy-pyridine|CS-W003621

Structure of 64436-92-6

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General Information

  • CAS No. 64436-92-6
  • Cat. No. CS-W003621
  • Purity ≥98%
  • MDL No. MFCD09701369
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 5-Methoxy-pyridin-3-ylamine
  • SMILES COc1cc(N)cnc1

Description

3-Amino-5-methoxypyridine is a bench-stable heterocyclic building block featuring an electron-rich pyridine core. The amino group at the 3-position enables direct functionalization, while the para-oriented methoxy substituent enhances solubility and modulates electronic properties. This compound integrates efficiently into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

3-Amino-5-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. The amino group facilitates direct electrophilic substitution and coupling reactions, while the methoxy substituent provides orthogonal reactivity and enhanced solubility. Its bench-stable nature and compatibility with standard synthetic transformations make it well-suited for multi-step synthesis of heterocyclic APIs and drug candidates.

Synthesis

  • Route1

    References

    • Fantasia, Serena; Windisch, Johannes; Scalone, Michelangelo Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 627 - 631
  • Route2
    • In-stock
      3-Bromo-5-methoxypyridine|CS-W007427
      50720-12-2
    • ~91%
    • null|null
      1445972-34-8
    • In-stock
      3-Amino-5-methoxy-pyridine|CS-W003621
      64436-92-6

    References

    • Organic Letters, , vol. 15, # 14 p. 3734 - 3737
  • Route3
    • null|null
      78156-40-8
    • ~93%
    • In-stock
      3-Amino-5-methoxy-pyridine|CS-W003621
      64436-92-6

    References

    • Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling Ching; Kiyokawa, Hiroshi; Ueno, Kyoji; Kita, Yasuyuki Heterocycles, 1981 , vol. 15, # 2 p. 871 - 874

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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