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CS-W001157 4
Total: USD 88.00

3-(Methylsulfonyl)propanoic acid

  • CAS No. 645-83-0

  • Cat. No. CS-0038744
  • Purity≥97%
  • MDL No.MFCD01697360
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(Methylsulfonyl)propanoic acid|CS-0038744

Structure of 645-83-0

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Description

This sulfonate-containing carboxylic acid features a methylsulfonyl group that enhances solubility and metabolic stability. The rigid, electron-withdrawing moiety integrates readily into bioactive scaffolds, offering improved polarity and reduced lipophilicity in drug discovery applications.

Application

3-(Methylsulfonyl)propanoic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable sulfone group adjacent to a carboxylic acid. Its well-defined reactivity facilitates amide bond formation and conjugation strategies, while the methylsulfonyl moiety enhances solubility and provides orthogonal functionalization potential. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it suitable for use in high-throughput synthesis and API intermediate development.

General Information

  • CAS No. 645-83-0
  • Cat. No. CS-0038744
  • Purity ≥97%
  • MDL No. MFCD01697360
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₄S
  • Molecular Weight 152.17
  • Synonym(s) Methylsulfonyl propionic acid
  • SMILES CS(=O)(=O)CCC(=O)O

Computational Chemistry Data

  • TPSA   71.44
  • LogP   -0.4943
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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