2-(2-Aminothiazol-4-yl)acetic acid hydrochloride

Name: 2-(2-Aminothiazol-4-yl)acetic acid hydrochloride
Brand: ChemScene
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CAS No. 66659-20-9
Cat. No. CS-0042604
Purity≥96%
MDL No.MFCD06658943

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-(2-Aminothiazol-4-yl)acetic acid hydrochloride|CS-0042604

Structure of 66659-20-9

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Description

This hydrochloride salt features a 2-aminothiazol-4-yl moiety linked to an acetic acid side chain, delivering enhanced solubility and stability under standard conditions. The scaffold integrates readily into peptide-based conjugates and bioactive molecules, serving as a robust building block for medicinal chemistry campaigns targeting kinase inhibition and antimicrobial agents.

Application

2-(2-Aminothiazol-4-yl)acetic acid hydrochloride serves as a key building block for thiazole-containing pharmaceuticals, enabling efficient access to bioactive scaffolds through standard amide coupling and electrophilic substitution reactions. Its amine functionality offers high reactivity in peptide synthesis and derivatization workflows, while the hydrochloride salt enhances solubility and bench stability. Functions reliably in diverse synthetic contexts requiring nitrogen heterocycles with orthogonal functional handles.

General Information

CAS No. 66659-20-9
Cat. No. CS-0042604
Purity ≥96%
MDL No. MFCD06658943
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₇ClN₂O₂S
Molecular Weight 194.64
Synonym(s) 2-amino-4-Thiazoleaceticacid
SMILES O=C(O)CC1=CSC(N)=N1.[H]Cl

Computational Chemistry Data

TPSA 76.21
LogP 0.7742
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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2-(2-Aminothiazol-4-yl)acetic acid hydrochloride

CAS No. 66659-20-9

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